This study is intended to assess the effectiveness of a low-dose high-frequency Helping Babies Breathe (HBB) training intervention on the knowledge and skills of community midwives in the four private secondary care hospitals in Karachi, Pakistan. This study used a quantitative research approach, using randomized controlled trials. The target population was Community midwives. A simple random sampling method was used and 94 participants were selected. The primary investigator (PI) has randomized the institution out of four study settings. Two from interventional group and two from controlled group. The duration of the study was four months, from October 2022 to February 2023. The developed and pre-tested modules and instruments were used which has 18 items. The score compared on knowledge before and after initial HBB training and after 2 months. Study results revealed that there was a significant difference present in the pair of pre-post, pre-follow- up, and post-follow-up phases.