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Declined Drug Susceptibility Mechanisms against Mycobacterium Tuberculosis

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Abstract

Anti-microbial treatment is extensively used in conventional tuberculosis treatment, leading to resistance development. In this review, we summarized the mode of action and susceptibility protocols of anti-Tubercular drugs. An effort to elucidate the role of genetic variations, cell membrane adaptions, and efflux pump modalities in treatment failure will be an asset in devising prospective strategies.

Authors

1-Shabana Gulzar Toor
Undergraduate Student, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.

2-Mohammad Faizan Asif
Undergraduate Student, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.

3-Hafsa Abbas
Undergraduate Student, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.

4-Gul Shehnaz
Chairperson, Department of Pharmacy, Faculty of Biological Sciences, Quaid I Azam University, Islamabad, Pakistan.

Keywords

Tuberculosis, Drug resistance, Mechanism of Action, Mutations

DOI Number

10.31703/giidr.2017(II-I).02

DOI Link

http://dx.doi.org/10.31703/giidr.2017(II-I).02

Page Nos

9-27

Volume & Issue

II - I

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Published: Dec 2017

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