AbstractCancer being a multifarious disease, can be mutated in many ways so that it can enhance the process of
proliferation, invasion through an overactive cellular cycle and cell division and by antibacterial and
chemotherapeutic drugs is highly guaranteed. The cells can prevent the development of apoptosis by the
absence of (TP53) protein i-e tumor suppressor gene, in the necrosis, inflammatory signals especially that
invade immune cells, which promote invasion and malignancy. Cancer cells can form their own factors and
growth ligands which may include the peptides such as Bombesin (secreted by the small cells in lung cancer).
It activates both the invasion and the metastasis by forming changes in shape and attachment to the outer
matrix of neighboring cell. The paper presents classes of anti-mitotic compounds, the overview of the molecular
mechanism of action of anti-mitotic agents, including Bevacizumab, trastuzumab, Mechlorethamine and
paclitaxel, and a demonstration of many other anti-mitotic chemical limitations.
1-Gul Shehnaz Chairperson, Department of Pharmacy, Faculty of Biological Sciences, Quaid I Azam University, Islamabad, Pakistan.(Corresponding Author)2-Sana Ali Zahra Undergrad Student, Department of Pharmacy, Faculty of Biological Sciences, Quaid I Azam University, Islamabad, Pakistan.3-Syeda Komal Fatima Undergrad Student, Department of Pharmacy, Faculty of Biological Sciences, Quaid I Azam University, Islamabad, Pakistan.
KeywordsCancer, Chemotherapeutic Drugs, Apoptosis, Tumor Suppressor Gene, Invasion, Metastasis
Volume & IssueII - I