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An Insight of Mechanism of Action of Four Anti-Cancer Drugs

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Abstract

Cancer being a multifarious disease, can be mutated in many ways so that it can enhance the process of proliferation, invasion through an overactive cellular cycle and cell division and by antibacterial and chemotherapeutic drugs is highly guaranteed. The cells can prevent the development of apoptosis by the absence of (TP53) protein i-e tumor suppressor gene, in the necrosis, inflammatory signals especially that invade immune cells, which promote invasion and malignancy. Cancer cells can form their own factors and growth ligands which may include the peptides such as Bombesin (secreted by the small cells in lung cancer). It activates both the invasion and the metastasis by forming changes in shape and attachment to the outer matrix of neighboring cell. The paper presents classes of anti-mitotic compounds, the overview of the molecular mechanism of action of anti-mitotic agents, including Bevacizumab, trastuzumab, Mechlorethamine and paclitaxel, and a demonstration of many other anti-mitotic chemical limitations.

Authors

1-Gul Shehnaz
Chairperson, Department of Pharmacy, Faculty of Biological Sciences, Quaid I Azam University, Islamabad, Pakistan.(Corresponding Author)

2-Sana Ali Zahra
Undergrad Student, Department of Pharmacy, Faculty of Biological Sciences, Quaid I Azam University, Islamabad, Pakistan.

3-Syeda Komal Fatima
Undergrad Student, Department of Pharmacy, Faculty of Biological Sciences, Quaid I Azam University, Islamabad, Pakistan.

Keywords

Cancer, Chemotherapeutic Drugs, Apoptosis, Tumor Suppressor Gene, Invasion, Metastasis

DOI Number

10.31703/giidr.2017(II-I).04

DOI Link

http://dx.doi.org/10.31703/giidr.2017(II-I).04

Page Nos

41-48

Volume & Issue

II - I

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Published: Dec 2017

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